06+HIV-AIDS

=02-11= Hiv could cause problems in the axons both of the brain and the peripheral nerves. Leading to cognitive problems and neuropathy. The underlying could be associated to the mitochondria of the axons. My impression is the the energy production is impaired but that this is only a part of the pathological mechanism. In the mitochondria the effect seems to be more at the outer membrane than at the inner. Since the transport system does not appear to be directly involved. First treatment of just a couple of weeks seem to have a positive effect.

The effect of early antiretroviral medication with zidovudine on neurophysiological functions was evaluated in subjects with asymptomatic HIV-l infection. Patients were recruited participants of a larger double-blind randomised placebo-controlled treatment trial with zidovudine (Concorde). The main outcome measures included: quantitative electroencephalography (QEEG), auditory event-related potentials (AEP) and pattern-reversal visual evoked potentials (PRVEP), as well as standard clinical, virological and immunological markers. No significant impairment and no difference between treatment groups was found in visual PlOO latency and auditory long-latency P3 responses which is in agreement with the absence of neurological and neuropsychological impairment over the study period. Significant treatment effects were revealed by quantitative electroencephalography (QEEG). While the placebo group showed a significant increase in delta and theta slow frequency QEEG activity over the study period, slow wave amplitude remained unchanged in the zidovudine group after a mean follow-up period of 28 months. In summary, the data provide evidence for a low level neuropathological process in asymptomatic HIV-l infection which can be effectively suppressed by antiretroviral medication. 