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01 Regions and Therapies
03c1 low Alpha
03c2 high Alpha
03d Beta 1
03e Beta 2
03f Beta 3
03h Coherence, phase loch,shift
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12 Anatomy and Physiology
Table of Contents
file:Origin of the EEG.pdf
file:The Anterior Insula and Human Awareness.pdf
Progressive non-fluent aphasia
Other clinical conditions
Forebrain asymmetry of emotion
Origin of the EEG.pdf
, the inventor of the
was the first to propose the idea that the brain is constantly busy. In a series of papers published in 1929 he showed that the electrical oscillations detected by his device do not cease even when the subject is at rest. However his ideas were not taken seriously and a general perception formed among neurologists that only when a focused activity is performed does the brain (or a part of the brain) becomes active.
Later, experiments by the group of neurologist Marcus E. Raichle's at
Washington University School of Medicine
and other groups showed that the brain's energy consumption is increased by less than 5% of its baseline energy consumption while performing a focused mental task. These experiments showed that the brain is constantly active with a high level of activity even when the person is not engaged in focused mental work. Research thereafter focused on finding the regions responsible for this constant background activity level.
Raichle coined the term "default mode" in 2001 to describe resting state brain function;
] the concept rapidly became a central theme in
] The brain has other Low Frequency Resting State Networks (LFRSNs), such as visual and auditory networks.
Serotonin is a neurotransmitter, and is found in all
, where it mediates gut movements and the animal's perception of resource availability. In the simplest animals, resources are equivalent with food, but in advanced animals such as
, resources also can mean social dominance. In response to the perceived abundance or scarcity of resources, the animal's growth, reproduction or
may be elevated or lowered. Recent studies involving the serotonin transporter gene 5-HTT have shown the short allele of this gene increases synaptic serotonin levels. These genetic studies have demonstrated serotonin has strong associations with depression in regards to a negative environment.
The neurons of the
are the principal source of 5-HT release in the brain.
] The raphe nuclei are neurons grouped into about nine pairs and distributed along the entire length of the
, centered around the
] Axons from the neurons of the raphe nuclei form a
, reaching almost every part of the central nervous system. Axons of neurons in the lower
terminate in the
, while the axons of the higher nuclei spread out in the entire brain.
Serotonin is released into the space between neurons, and diffuses over a relatively wide gap (>20 µm) to activate
located on the
, cell bodies and
of adjacent neurons.
for serotonin. They are located on the cell membrane of
and other cell types in animals, and mediate the effects of serotonin as the
and of a broad range of pharmaceutical and
. With the exception of the
, a ligand-gated
, all other 5-HT receptors are
G protein-coupled, seven transmembrane
) receptors that activate an
Serotonergic action is terminated primarily via
of 5-HT from the synapse. This is accomplished through the specific
, on the presynaptic neuron. Various agents can inhibit 5-HT reuptake, including
selective serotonin reuptake inhibitors
(SSRIs). Interestingly, a 2006 study conducted by the
University of Washington
suggested a newly discovered monoamine transporter, known as
, may account for "a significant percentage of 5-HT clearance".
] Contrasting with the high-affinity SERT, the PMAT has been identified as a low-affinity transporter, with an apparent Km of 114 micromoles/L for serotonin; approximately 230 times higher than that of SERT. However, the PMAT, despite its relatively low serotonergic affinity, has a considerably higher transport
than SERT, "..resulting in roughly comparable uptake efficiencies to SERT in heterologous expression systems." The study also suggests some SSRIs, such as
, inhibit PMAT but at
values which surpass the therapeutic plasma concentrations by up to four orders of magnitude; therefore, SSRI monotherapy is
in PMAT inhibition. At present, there are no known pharmaceuticals which would appreciably inhibit PMAT at normal therapeutic doses. The PMAT also suggestively transports dopamine and norepinephrine, albeit at Km values even higher than that of 5-HT (330–15,000 μmoles/L).
Serotonin can also signal through a nonreceptor mechanism called serotonylation, in which serotonin modifies proteins.
] This process underlies serotonin effects upon platelet-forming cells (
) in which it links to the modification of signaling enzymes called
that then trigger the release of vesicle contents by
] A similar process underlies the pancreatic release of insulin.
] The effects of serotonin upon vascular smooth muscle "tone" (this is the biological function from which serotonin originally got its name) depend upon the serotonylation of proteins involved in the contractile apparatus of muscle cells.
(or Paleomammalian brain) is a set of brain structures including the
anterior thalamic nuclei
and fornix, which seemingly support a variety of functions including
long term memory
] The term "limbic" comes from the
, for "border" or "edge". Some scientists have suggested that the concept of the limbic system should be abandoned as
, as it is grounded more in transient tradition than in facts.
The limbic system is the set of
structures that forms the inner border of the cortex. In an abstract topological sense, each cortical hemisphere can be thought of as a sphere of gray matter, with a hole punched through it in the area where nerve fibers connect it to the subcortical structures of the basal forebrain. The hole is surrounded by a ring of cortical and noncortical areas that combine to make up the limbic system. The cortical components generally have fewer layers than the classical 6-layered
, and are often classified as
The limbic system includes many structures in the
. The term has been used within psychiatry and neurology, although its exact role and definition have been revised considerably since the term was introduced.
] The following structures are, or have been considered to be, part of the limbic system:
] Involved in signaling the cortex of motivationally significant stimuli such as those related to reward and fear in addition to social functions such as mating.
] Required for the formation of
and implicated in maintenance of cognitive maps for navigation.
] Plays a role in the formation of spatial memory
] Autonomic functions regulating
and cognitive and
] carries signals from the
] Regulates the autonomic nervous system via
production and release. Affects and regulates
, and the
] The "relay station" to the cerebral cortex.
In addition, these structures are sometimes also considered to be part of the limbic system:
] Important for the formation of memory
] thought to contribute to new
and to regulate happiness.
: Important memory and associative components.
] The function of which relates to the
: Region encompassing the cingulate, hippocampus, and parahippocampal gyrus
: Olfactory sensory input
: Involved in reward,
: Required for
The limbic system operates by influencing the
autonomic nervous system
. It is highly interconnected with the
, the brain's
, which plays a role in
and the "high" derived from certain
. These responses are heavily modulated by
projections from the limbic system. In 1954, Olds and Milner found that
implanted into their
as well as their
repeatedly pressed a lever activating this region, and did so in preference to eating and drinking, eventually dying of exhaustion.
The limbic system is also tightly connected to the
. Some scientists contend that this connection is related to the pleasure obtained from solving problems. To cure severe emotional disorders, this connection was sometimes surgically severed, a procedure of
, called a
(this is actually a misnomer). Patients who underwent this procedure often became passive and lacked all motivation.
Paul D. MacLean
, as part of his
theory, hypothesized that the limbic system is older than other parts of the brain, and that it developed to manage
fight or flight
circuitry which is an evolutionary necessity for reptiles as well as humans. However, recent studies of the limbic system of
have challenged some long-held tenets of forebrain evolution. The common ancestors of reptiles and
had a well-developed limbic system in which the basic subdivisions and connections of the amygdalar nuclei were established.
The French physician
first called this part of the brain "le grand lobe limbique" in 1878,
] but most of its putative role in emotion was developed only in 1937 when the American physician
described his anatomical model of emotion, the
Paul D. MacLean
expanded these ideas to include additional structures in a more dispersed "limbic system," more on the lines of the system described above.
] The term was formally introduced by
Paul D. MacLean
in 1952. The concept of the limbic system has since been further expanded and developed by
Still, there remains much controversy over the use of the term. When it was first coined, it was posited as the emotional center of the brain, with cognition being the business of the
by contrast. However, this almost immediately ran into trouble when damage to the
, a primary limbic structure, was shown to result in severe cognitive (memory) deficits. And since its inception, the delineating boundaries of the limbic system have been changed again and again by the community. More recently, attempts have been made to salvage the concept through more precise definition, but there are still no generally accepted criteria for defining its parts. As a concept grounded more in tradition than in facts, many scientists have suggested that the concept should be considered
Electrode Locations and Broadmann Areas.pdf
The Anterior Insula and Human Awareness.pdf
| The anterior insular cortex (AIC) is implicated in a wide range of conditions and behaviours, from bowel distension and orgasm, to cigarette craving and
maternal love, to decision making and sudden insight. Its function in the re-representation of interoception offers one possible basis for its involvement in all subjective feelings. New findings suggest a fundamental role for the AIC (and the von conomo neurons it contains) in awareness, and thus it needs to be considered as a potential neural correlate of consciousness.
The evidence at that time indicated that the anterior insular cortex (AIC) (FIG. 1) contains interoceptive rerepresentations that substantialize (that is, provide the basis for) all subjective feelings from the body and perhaps emotional awareness, consistent with the essence of the James–Lange theory of emotion and Damasio’s ‘somatic marker’ hypothesis.
Interoceptive stimuli that have been shown to activate the AIC include thirst, dyspnea, ‘air hunger’, the Valsalva manoeuvre, sensual touch, itch, penile stimulation, sexual arousal, coolness, warmth, exercise, heartbeat, winetasting (in sommeliers), and distension of the bladder, stomach, rectum or oesophagus (see Supplementary information S1 (table)).
In each of the the
, insulary cortex or insular lobe) is a portion of the folded deep within the between the and the frontal lobe. The cortical area overlying it towards the lateral surface of the brain is the
(meaning "lid"). The opercula are formed from parts of the enclosing frontal, temporal and parietal lobes. It is believed to be involved in consciousness.
The insular cortex is divided into two parts: the larger anterior insula and the smaller posterior insula in which more than a dozen field areas have been identified.
The insulae play a role in diverse functions usually linked to
or the regulation of the body's
. These functions include perception, motor control, self-awareness, cognitive functioning, and interpersonal experience. Related to these it is involved in
The insula was first described by
Johann Christian Reil
while describing cranial and spinal nerves and plexi.[[#cite_note-Binder-0|][[#cite_note-Binder-0|1]][[#cite_note-Binder-0|]]]
is responsible for it being known as the
Island of Reil
The right anterior insula aids
awareness of body states, such as the ability to time one's own
. Moreover, greater right anterior insular
volume correlates with increased accuracy in this subjective sense of the inner body, and with negative emotional experience.[[#cite_note-1|][[#cite_note-1|2]][[#cite_note-1|]]] It is also involved in the control of
,[[#cite_note-Lamb-2|][[#cite_note-Lamb-2|3]][[#cite_note-Lamb-2|]]] particularly during and after exercise.[[#cite_note-Lamb-2|][[#cite_note-Lamb-2|3]][[#cite_note-Lamb-2|]]] It is also activated when the brain perceives greater
The insular cortex also is where the sensation of
is judged as to its degree.[[#cite_note-5|][[#cite_note-5|6]][[#cite_note-5|]]] Further, the insula is where a person imagines pain when looking at images of painful events while thinking about them happening to one's own body.[[#cite_note-6|][[#cite_note-6|7]][[#cite_note-6|]]] Those with
irritable bowel syndrome
have abnormal processing of
pain in the insular cortex related to dysfunctional inhibition of pain within the brain.[[#cite_note-7|][[#cite_note-7|8]][[#cite_note-7|]]]
Another perception of the right anterior insula is the degree of nonpainful
[[#cite_note-8|][[#cite_note-8|9]][[#cite_note-8|]]] or nonpainful coldness[[#cite_note-9|][[#cite_note-9|10]][[#cite_note-9|]]] of a skin sensation. Other internal sensations processed by the insula include stomach or
.[[#cite_note-10|][[#cite_note-10|11]][[#cite_note-10|]]][[#cite_note-11|][[#cite_note-11|12]][[#cite_note-11|]]] A full
also activates the insular cortex.[[#cite_note-12|][[#cite_note-12|13]][[#cite_note-12|]]]
The cerebral cortex processing
sensations extends into the insula[[#cite_note-13|][[#cite_note-13|14]][[#cite_note-13|]]] with small lesions in the anterior insular cortex being able to cause loss of
Other noninteroceptive perceptions includes passive listening to music,[[#cite_note-15|][[#cite_note-15|16]][[#cite_note-15|]]] laughter and crying,[[#cite_note-16|][[#cite_note-16|17]][[#cite_note-16|]]], empathy and compassion,[[#cite_note-17|][[#cite_note-17|18]][[#cite_note-17|]]] and language [[#cite_note-18|][[#cite_note-18|19]][[#cite_note-18|]]]
In motor control it contributes to hand and eye motor movement,[[#cite_note-19|][[#cite_note-19|20]][[#cite_note-19|]]][[#cite_note-20|][[#cite_note-20|21]][[#cite_note-20|]]] swallowing,[[#cite_note-21|][[#cite_note-21|22]][[#cite_note-21|]]] gastric motility,[[#cite_note-22|][[#cite_note-22|23]][[#cite_note-22|]]] and speech articulation.[[#cite_note-23|][[#cite_note-23|24]][[#cite_note-23|]]][[#cite_note-24|][[#cite_note-24|25]][[#cite_note-24|]]] It has been identified as a "central command” centre that ensures that
increase at the onset of
.[[#cite_note-25|][[#cite_note-25|26]][[#cite_note-25|]]] Research upon conversation links it to the capacity for long and complex spoken sentences.[[#cite_note-26|][[#cite_note-26|27]][[#cite_note-26|]]] It is also involved in motor learning[[#cite_note-27|][[#cite_note-27|28]][[#cite_note-27|]]] and has been identified as playing a role in the motor recovery from stroke.[[#cite_note-28|][[#cite_note-28|29]][[#cite_note-28|]]]
In homeostasis, it controls autonomic functions through the regulation of the sympathetic and parasympathetic systems.[[#cite_note-29|][[#cite_note-29|30]][[#cite_note-29|]]][[#cite_note-Critchley-30|][[#cite_note-Critchley-30|31]][[#cite_note-Critchley-30|]]] It has a role in regulating the
It has been identified as playing a role in the experience of bodily self-awareness, sense of agency and sense body ownership.
The anterior insular processes a person's sense of
both to smells and to the sight of contamination and mutilation — even when just imagining the experience. This associates with a
like link between external and internal experience.
In social experience it is involved in the processing of norm violations, emotional processing, empathy, and orgasms.
The insular cortex, in particular its most anterior portion, is considered a
-related cortex. The insula has increasingly become the focus of attention for its role in body representation and subjective emotional experience. In particular,
has proposed that this region plays a role in mapping visceral states that are associated with emotional experience, giving rise to conscious feelings. This is in essence a neurobiological formulation of the ideas of
who first proposed that subjective emotional experience (i.e. feelings) arise from our brain's interpretation of bodily states that are elicited by emotional events
. This is an example of
Functionally speaking, the insula is believed to process convergent information to produce an
emotionally relevant context for sensory experience
. More specifically, the anterior insula is related more to
olfactory, gustatory, vicero-autonomic, and limbic function
, while the posterior insula is related more to
Functional imaging experiments
have revealed that the insula has an important role in
experience and the experience of a number of basic
, including anger, fear,
, happiness and sadness.
Functional imaging studies have also implicated the insula in conscious desires, such as food craving and drug craving. What is common to all of these emotional states is that they each change the body in some way and are associated with highly salient subjective qualities. The insula is well situated for the integration of information relating to bodily states into higher-order cognitive and emotional processes. The insula receives information from "homeostatic afferent" sensory pathways via the thalamus and sends output to a number of other limbic-related structures, such as the [[wiki/Amygdala|
, as well as to motor cortices.[[#cite_note-45|][[#cite_note-45|46]][[#cite_note-45|]]]
A study using
magnetic resonance imaging
has found that the right anterior insula was significantly thicker in people who
Another study using voxel-based morphometry and MRI on experienced Vipassana meditators was done to extend the findings of Lezar et al., which found increased grey matter concentrations in this and other areas of the brain in experienced meditators.[[#cite_note-47|][[#cite_note-47|48]][[#cite_note-47|]]]
research suggests the insula is involved in two types of salience. Interoceptive information processing that links interoception with emotional salience to generate a subjective representation of the body. This involves the anterior insular cortex with the pregenual anterior cingulate cortex (
Brodmann area 33
) and the anterior and posterior mid-cingulate cortices. Second, a general salience system concerned with environmental monitoring, response selection, and skeletomotor body orientation that involves all of the insular cortex and the mid-cingulate cortex.[[#cite_note-48|][[#cite_note-48|49]][[#cite_note-48|]]]
An alternative or perhaps complementary proposal is that right anterior insular regulates the interaction between the salience of the
created to achieve a task (the dorsal attention system) and the salience of
created to keep focused upon the relevant part of the environment (ventral attention system).[[#cite_note-Eckert-49|][[#cite_note-Eckert-49|50]][[#cite_note-Eckert-49|]]] This regulation of salience might be particularly important during challenging tasks where attention might
and so cause careless mistakes but if there is too much arousal it risks creating poor performance by turning into
The anterior insula receives a direct projection from the basal part of the [[w/index.php?title=Ventral_medial_nucleus&action=edit&redlink=1|ventral medial nucleus]] (VMb) of the thalamus and a particularly large input from the central nucleus of the
. Additionally, the anterior insula itself projects to the amygdala. The posterior insula connects reciprocally with the secondary
primary sensory cortex
(S2) and receives input from spinothalamically activated [[w/index.php?title=Ventral_posterior_inferior&action=edit&redlink=1|ventral posterior inferior]] (VPI) thalamic nuclei. More recent work by [[w/index.php?title=Bud_Craig&action=edit&redlink=1|Bud Craig]] and his colleagues has shown that this region receives inputs from the ventromedial nucleus (posterior part) of the thalamus that are highly specialized to convey emotional/homeostatic information such as pain, temperature, itch, local oxygen status and sensual touch.
The insular cortex has regions of variable cell structure or
, changing from granular in the
portion to agranular in the
portion. The insula also receives differential cortical and
input along its length.
The insular cortex is considered a separate
by some authorities.[[#cite_note-50|][[#cite_note-50|51]][[#cite_note-50|]]] Other sources see the insula as a part of the
.[[#cite_note-51|][[#cite_note-51|52]][[#cite_note-51|]]] It is also sometimes grouped with limbic structures deep in the brain into a
As a paralimbic cortex, the insular cortex is considered to be a relatively old structure. It plays a role in a variety of highly conserved functions that are related to basic survival needs, such as taste, visceral sensation and autonomic control (so-called homeostatic functions). There is evidence that in addition to its more conserved functions, the insula may play a role in certain "higher" functions that operate only in humans and other great apes.
and his colleagues have shown that the anterior insular cortex contains a population of neurons, called
, that are specific to great apes. These neurons are also found in the
anterior cingulate cortex
, which is another region that has reached a high level of specialization in great apes. Spindle neurons are found at a higher density in the right insular cortex. It has been speculated that these neurons are involved in cognitive-emotional processes that are specific to great apes, such as
and self-aware emotional feelings. This is supported by functional imaging results showing that the structure and function of the right anterior insula are correlated with the ability to feel one's own heartbeat, or to empathize with the pain of others. It is thought that these functions are not distinct from the "lower" functions of the insula, but rather arise as a consequence of the role of the insula in conveying homeostatic information to consciousness
Progressive non-fluent aphasia
Progressive non-fluent aphasia is the deterioration of normal language function which causes individuals to lose the ability to communicate fluently while being still being able to comprehend single words and intact other non-linguistic cognition. It is found in a variety of degenerative neurological conditions including
motor neuron disease
. It is associated with hypometabolism[[#cite_note-52|][[#cite_note-52|53]][[#cite_note-52|]]] and atrophy of the left anterior insular cortex.[[#cite_note-53|][[#cite_note-53|54]][[#cite_note-53|]]]
"The insula also reads body states like hunger and craving and helps push people into reaching for the next sandwich, cigarette or line of cocaine." [[#cite_note-54|][[#cite_note-54|55]][[#cite_note-54|]]] A number of functional brain imaging studies have shown that the insular cortex is activated when drug abusers are exposed to environmental cues that trigger cravings. This has been shown for a variety of drugs of abuse, including
. Despite these findings, the insula has been ignored within the drug addiciton literature, perhaps because it is not known to be a direct target of the mesotelencephalic
system which is central to current dopamine reward theories of addiction. Recent research [[#cite_note-55|][[#cite_note-55|56]][[#cite_note-55|]]] has shown that
smokers who suffer damage to the insular cortex, from a
for instance, have their addiction to cigarettes practically eliminated. However, the study was conducted on average eight years after the strokes, and the author admits
could affect the results[[#cite_note-56|][[#cite_note-56|57]][[#cite_note-56|]]]
These individuals were found to be up to 136 times more likely to undergo a disruption of smoking addiction than smokers with damage in other areas. Disruption of addiction was evidenced by self-reported behavior changes such as quitting smoking less than one day after the brain injury, quitting smoking with great ease, not smoking again after quitting, and having no urge to resume smoking since quitting. This suggests a significant role for the insular cortex in the neurological mechanisms underlying addiction to
and other drugs, and would make this area of the brain a possible target for novel anti-addiction medication. In addition, this finding suggests that functions mediated by the insula, especially conscious feelings, may be particularly important for maintaining drug addiction, although this view is not represented in any modern research or reviews of the subject.[[#cite_note-57|][[#cite_note-57|58]][[#cite_note-57|]]]
A recent study in rats by Contreras et al.[[#cite_note-58|][[#cite_note-58|59]][[#cite_note-58|]]] corroborates these findings by showing that reversible inactivation of the insula disrupts amphetamine
conditioned place preference
, an animal model of cue-induced drug craving. In this study, insula inactivation also disrupted "malaise" responses to lithium chloride injection, suggesting that the representation of negative interoceptive states by the insula plays a role in addiction. However, in this same study, the conditioned place preference took place immediately after the injection of amphetamine, suggesting that it was the immediate, pleasurable interoceptive effects of amphetamine administration, rather than the delayed, aversive effects of amphetamine withdrawal that are represented within the insula.
A model proposed by Naqvi et al. (see above) is that the insula stores a representation of the pleasurable interoceptive effects of drug use (e.g. the airway sensory effects of nicotine, the cardiovascular effects of amphetamine), and that this representation is activated by exposure to cues that have previously been associated with drug use. A number of functional imaging studies have shown the insula to be activated during the administration of drugs of abuse. Several functional imaging studies have also shown that the insula is activated when drug users are exposed to drug cues, and that this activity is correlated with subjective urges. In the cue-exposure studies, insula activity is elicited when there is no actual change in the level of drug in the body. Therefore, rather than merely representing the interoceptive effects of drug use as it occurs, the insula may play a role in memory for the pleasurable interoceptive effects of past drug use, anticipation of these effects in the future, or both. Such a representation may give rise to conscious urges that feel as if they arise from within the body. This may make addicts feel as if their bodies need to use a drug, and may result in persons with lesions in the insula reporting that their bodies have forgotten the urge to use, according to this study.
Other clinical conditions
The insular cortex has been suggested to have a role in anxiety disorders,[[#cite_note-59|][[#cite_note-59|60]][[#cite_note-59|]]] and emotion dysregulation.[[#cite_note-60|][[#cite_note-60|61]][[#cite_note-60|]]]
Forebrain asymmetry of emotion
The Anterior Insula and Human Awareness.pdf
There are two sides of the brain, and so if there are separate time-based representations of the sentient self that subserve awareness in the anterior insular cortex (AIC) (one in each side), how are they coordinated to generate one unified self? The homeostatic model of awareness presented in this and prior articles1,78 suggests that there is an energy efficiency-optimal process that is based on the coordinated opponency of the autonomic system — that activity in the right side of the forebrain is associated with energy expenditure, sympathetic activity, arousal, withdrawal (aversive) behaviour and individual-oriented (survival) emotions, and activity in the left side is associated with energy nourishment, parasympathetic activity, relaxation, approach (appetitive) behaviour and group-oriented (affiliative) emotions. This proposal is described in detail in prior articles78,95. Briefly, the origin of this asymmetry can be related to the asymmetric autonomic innervation of the heart, and its evolutionary development would have been compelled by the need for energy optimization in the brain (which consumes 25% of the body’s energy). This model fits with an accumulating body of psychophysical literature which indicates that the left and right forebrain halves are differentially associated with positive and negative affect96 and, importantly, with the anatomical and functional asymmetry in the homeostatic afferent input to the insular cortex5,97,98 and in forebrain cardiac control99. It can explain why under particular conditions the AIC is more active on one side (FIG. 2) but also why in most conditions the two sides display joint activity, which mirrors the coordinated sympathetic and parasympathetic control of the heart. The model offers explanations for why positive emotions can reduce or block negative emotions (and vice versa), why the left (affiliative, vagal) side controls deictic pointing and verbal communication, and how increased parasympathetic activity (for example, activation of vagal afferents by gastric distension, slow breathing or elecrical stimulation) can reduce negative emotions (for example, pain). Given the many asymmetries in the activations of the AIC noted in this article, investigations addressing this model in split-brain patients could be enlightening, particularly if performed with those rare patients in whom boththe corpus callosum and the anterior commissure are sectioned100,101.
both when an animal acts and when the animal observes the same action performed by another.
] Thus, the neuron "mirrors" the behavior of the other, as though the observer were itself acting. Such neurons have been directly observed in
and other species including
. In humans, brain activity consistent with that of mirror neurons has been found in the
supplementary motor area
primary somatosensory cortex
inferior parietal cortex
Some scientists consider mirror neurons one of the most important recent discoveries in
. Among them is
, who believes they might be very important in
] However, despite the excitement generated by these findings, to date no widely accepted neural or
have been put forward to describe how mirror neuron activity supports cognitive functions such as imitation.
The function of the mirror system is a subject of much speculation. Many researchers in cognitive neuroscience and cognitive psychology consider that this system provides the physiological mechanism for the perception action coupling (see the
common coding theory
). These mirror neurons may be important for understanding the actions of other people, and for learning new skills by imitation. Some researchers also speculate that mirror systems may simulate observed actions, and thus contribute to
theory of mind
] while others relate mirror neurons to
] It has also been proposed that problems with the mirror system may underlie cognitive disorders, particularly
] However the connection between mirror neuron dysfunction and autism is tentative and it remains to be seen how mirror neurons may be related to many of the important characteristics of autism.
In the 1980s and 1990s,
was working with Giuseppe Di Pellegrino,
, Leonardo Fogassi, and
University of Parma
. These neurophysiologists had placed
in the ventral premotor cortex of the
monkey to study
specialized for the control of hand and mouth actions; for example, taking hold of an object and manipulating it. During each experiment, they recorded from a single neuron in the monkey's brain while the monkey was allowed to reach for pieces of food, so the researchers could measure the neuron's response to certain movements.
] The discovery was initially sent to
but was rejected for its “lack of general interest”.
] They found that some of the neurons they recorded from would respond when the monkey saw a person pick up a piece of food as well as when the monkey picked up the food.
A few years later, the same group published another empirical paper and discussed the role of the mirror neuron system in action recognition, and proposed that the human
region of the monkey ventral premotor cortex.
Further experiments confirmed that about 10% of neurons in the monkey inferior frontal and inferior parietal cortex have 'mirror' properties and give similar responses to performed hand actions and observed actions. More recently Christian Keysers and colleagues have shown that, in both humans and monkeys, the mirror system also responds to the sound of actions.
Reports on mirror neurons have been widely published
] and confirmed
] with mirror neurons found in both inferior frontal and inferior parietal regions of the brain. Recently, evidence from
strongly suggests that humans have similar mirror neurons systems: researchers have identified brain regions which respond during both action and observation of action. Not surprisingly, these brain regions include those found in the macaque monkey.
functional magnetic resonance imaging
(fMRI) can examine the entire brain at once and suggests that a much wider network of brain areas shows mirror properties in humans than previously thought. These additional areas include the
and are thought to make the observer feel what it feels like to move in the observed way
26.1.11: could an arrhythmia be treated by training this area? Since it is closely related to the cingualte gyrus it also connected to emotions.
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